The leading exponent of Metaphysical painting. After studying in Athens and Munich, in 1911 he went to Paris with his brother, where he was noticed by Apollinaire. In 1915 he moved to Ferrara, where through his encounter with Carrà, Morandi and De Pisis, his metaphysical vision took definitive shape (the series of Metaphysical Interiors, "The Disquieting Muses", 1918). Together, the group strove to convey melancholy, enigma, the haunting loneliness of space and the elusive evocativeness of objects. In 1918 he put his name to a return to tradition and joined Mario Broglio's "Valori Plastici" magazine. His later painting marked a return to his imagery of the 1920s and '30s.